925681-61-4
925681-61-4 structure
- Name: Trabedersen
- Chemical Name: Trabedersen
- CAS Number: 925681-61-4
- Molecular Formula:
- Molecular Weight: 5770.75
- Catalog: Signaling Pathways Stem Cell/Wnt TGF-beta/Smad
- Create Date: 2023-01-12 12:07:42
- Modify Date: 2024-04-07 02:21:52
-
Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon[1][2].
| Name | Trabedersen |
|---|
| Description | Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Trabedersen (1-80 μM; 7 days) 减少人胰腺癌细胞系 Hup-T3 中 TGF-β2 的分泌，IC50 在低 μM 范围内，明显抑制细胞增殖，并完全阻断迁移 胰腺癌细胞[2]。 Trabedersen 逆转 TGF-β2 介导的胰腺癌细胞免疫抑制[2]。 Cell Proliferation Assay[2] Cell Line: Hup-T3 cells Concentration: 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM, 60 μM, 80 μM Incubation Time: 7 days Result: Inhibited cell proliferation, and completely blocked migration of pancreatic cancer cells. |
| In Vivo | Trabedersen（初始负荷剂量为 50 mg/kg ，随后每周 3 次 16 mg/kg；i.p.）可显著降低转移性胰腺癌原位小鼠模型中的肿瘤生长、淋巴结转移和血管生成[2]。 Animal Model: Eight-week-old male athymic nude mice (BALB⁄Cnu ⁄nu) bearing human pancreatic cancer cells[2]. Dosage: Initial loading dose of 50 mg/kg bodyweight followed by 16 mg/kg three times a week. Administration: Intraperitoneal (i.p.) injection; three times a week; for 27 days Result: Significantly reduced tumor growth, lymph node metastasis and angiogenesis. |
| References |
| Molecular Weight | 5770.75 |
|---|