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2719690-99-8

2719690-99-8 structure

2719690-99-8 structure

Name: AZ7550-d5
Chemical Name: AZ7550-d5
CAS Number: 2719690-99-8
Molecular Formula: C₂₇H₂₆D₅N₇O₂
Molecular Weight: 490.61
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-02-02 23:40:50
Modify Date: 2024-04-06 01:39:10
AZ7550-d5 is the deuterium labeled AZ7550 (HY-B0794). AZ7550, an active metabolite of AZD9291 (HY-15772), inhibits the activity of IGF1R with an IC50 of 1.6 μM[1][2].

Name	AZ7550-d5

Description	AZ7550-d5 is the deuterium labeled AZ7550 (HY-B0794). AZ7550, an active metabolite of AZD9291 (HY-15772), inhibits the activity of IGF1R with an IC50 of 1.6 μM[1][2].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> EGFR Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R
In Vitro	AZ7550-d5 (化合物 M6) 在人肝微粒体中产生的代谢物相对丰度为 15.58%[1]。
References	[1]. Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937. [2]. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

Molecular Formula	C₂₇H₂₆D₅N₇O₂
Molecular Weight	490.61

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