1345853-49-7

1345853-49-7 structure

Name: Dynamin IN-2
Chemical Name: Dynamin IN-2
CAS Number: 1345853-49-7
Molecular Formula: C₂₂H₂₁ClN₂O
Molecular Weight: 364.87
Catalog: Signaling Pathways Cytoskeleton Dynamin
Create Date: 2023-01-27 12:35:21
Modify Date: 2024-04-10 19:07:51
Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM[1].

Name	Dynamin IN-2

Description	Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Cytoskeleton >> Dynamin
Target	IC50: 1.0 ± 0.2 μM (dyn I GTPase), 9.5 ± 2.5 μM (CME)[1]
References	[1]. Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.

Molecular Formula	C₂₂H₂₁ClN₂O
Molecular Weight	364.87