915392-44-8
915392-44-8 structure
- Name: Ipomoeassin F
- Chemical Name: Ipomoeassin F
- CAS Number: 915392-44-8
- Molecular Formula: C44H62O15
- Molecular Weight: 830.95
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2023-03-02 18:08:50
- Modify Date: 2024-09-07 16:48:55
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Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs[1][2][3].
| Name | Ipomoeassin F |
|---|
| Description | Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Ipomoeassin F (1-500 nM; 24 小时) 有效抑制 α1AT 易位到 ER[1]。 Ipomoeassin F 在人卵巢癌细胞系 A2780 中具有很强的活性，IC50 值为 0.036 μM[2]。 Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 1, 5, 10, 25, 50, 75, 100, 250, 500 nM Incubation Time: 24 h Result: Downregulated cellular ATP levels and inhibited Sec61-mediated protein translocation with comparable potency. |
| References |
| Molecular Formula | C44H62O15 |
|---|---|
| Molecular Weight | 830.95 |