945781-29-3
945781-29-3 structure
- Name: Placulumab
- Chemical Name: Placulumab
- CAS Number: 945781-29-3
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2023-03-06 12:16:58
- Modify Date: 2024-04-09 21:53:28
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Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1].
| Name | Placulumab |
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| Description | Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1]. |
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| Related Catalog | |
| In Vitro | Placulumab (0.01-1000 µg/mL) 对 NS0 细胞和外周血单个核细胞 (PBMC) 具有细胞毒性[1]。 |
| In Vivo | Placulumab (0.3、1、3 和 10 mg/kg；腹腔注射；每周两次持续 8 周) 在 Tg197 转基因小鼠模型中具有有效的抗关节炎特性[1]。 Placulumab 在食蟹猴中的药代动力学 (PK) 参数[1] Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h) Clearance CL (mL/hr/kg) Intravenous injection (Males) 50 46000000 1320000 0.167 104 0.985 Intravenous injection (Females) 50 43300000 1020000 0.211 97.4 1.06 Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Dose normalize exposure AUC0-336 h (norm) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h) Subcutaneous injection (Males) 0.5 676000 1350000 3190 50.0 120 Subcutaneous injection (Females) 0.5 445000 890000 2880 48.0 108 Subcutaneous injection (Males) 5 3940000 788000 22700 40.0 117 Subcutaneous injection (Females) 5 3840000 767000 23800 12.0 109 Subcutaneous injection (Males) 50 41600000 832000 272000 40.0 122 Subcutaneous injection (Females) 50 32300000 646000 212000 32.0 107 |
| References |
| No Any Chemical & Physical Properties |