Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AD57
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1093380-42-7

1093380-42-7 structure

1093380-42-7 structure

Name: AD57
Chemical Name: AD57
CAS Number: 1093380-42-7
Molecular Formula: C₂₂H₂₀F₃N₇O
Molecular Weight: 455.44
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2023-04-04 18:42:53
Modify Date: 2026-07-15 10:11:30
AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1].

Name	AD57
Synonyms	1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea Urea, N-[4-[4-amino-1-(1-Methylethyl)-1H-pyrazolo[3,4-d]pyriMidin-3-yl]phenyl]-N'-[3-(trifluoroMethyl)phenyl] AD57, 10 mM in DMSO 1-{4-[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea

Description	AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> MAPK/ERK Pathway >> Raf Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)
Target	Braf
In Vitro	AD57 (0.2 nM) 显著抑制了 ptc > dRetMEN2B 在果蝇幼虫中的致死率[1]。 AD57 (0.1 nM) 通过减少 erk 基因剂量提高 ptc > dRetMEN2B 在果蝇中的存活率[1]。
In Vivo	AD57 抑制 RETMEN2 模型中 MEN2B (MZ-CRC-1) 和 MEN2A (TT) 患者来源细胞系的生存能力[1]。 AD57 (20 mg/kg) 在常规小鼠异种移植模型中显著抑制 TT 基肿瘤生长，无明显细胞毒性[1]。
References	[1]. Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 6;486(7401):80-4.

Molecular Formula	C₂₂H₂₀F₃N₇O
Molecular Weight	455.44

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