1093380-42-7
1093380-42-7 structure
- Name: AD57
- Chemical Name: AD57
- CAS Number: 1093380-42-7
- Molecular Formula: C22H20F3N7O
- Molecular Weight: 455.44
- Catalog: Signaling Pathways MAPK/ERK Pathway Raf
- Create Date: 2023-04-04 18:42:53
- Modify Date: 2024-09-10 12:49:27
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AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1].
| Name | AD57 |
|---|
| Description | AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Braf |
| In Vitro | AD57 (0.2 nM) 显著抑制了 ptc > dRetMEN2B 在果蝇幼虫中的致死率[1]。 AD57 (0.1 nM) 通过减少 erk 基因剂量提高 ptc > dRetMEN2B 在果蝇中的存活率[1]。 |
| In Vivo | AD57 抑制 RETMEN2 模型中 MEN2B (MZ-CRC-1) 和 MEN2A (TT) 患者来源细胞系的生存能力[1]。 AD57 (20 mg/kg) 在常规小鼠异种移植模型中显著抑制 TT 基肿瘤生长，无明显细胞毒性[1]。 |
| References |
| Molecular Formula | C22H20F3N7O |
|---|---|
| Molecular Weight | 455.44 |