2761367-25-1

2761367-25-1 structure

Name: Antiviral agent 25
Chemical Name: Antiviral agent 25
CAS Number: 2761367-25-1
Molecular Formula: C₁₅H₁₂FN₃S
Molecular Weight: 285.34
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-04-11 02:26:40
Modify Date: 2024-04-05 12:39:42
Antiviral agent 25 (compound 6g) is a new non-peptide analog covalent inhibitor of SARS-CoV-2 3CLpro. Antiviral agent 25 has a strong inhibitory effect on SARS-CoV-2 3CLpro and SARS-CoV-2 PLpro with IC50 values of 0.118 µM, 0.448 µM, respectively. Antiviral agent 25 has antiviral effect on SARS-CoV-2 with an EC50 value of 7.249 µM[1].

Name	Antiviral agent 25

Description	Antiviral agent 25 (compound 6g) is a new non-peptide analog covalent inhibitor of SARS-CoV-2 3CLpro. Antiviral agent 25 has a strong inhibitory effect on SARS-CoV-2 3CLpro and SARS-CoV-2 PLpro with IC50 values of 0.118 µM, 0.448 µM, respectively. Antiviral agent 25 has antiviral effect on SARS-CoV-2 with an EC50 value of 7.249 µM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	SARS-CoV-2 3CLpro:0.118 μM (IC50) SARS-CoV-2 PLpro:0.448 μM (IC50)
References	[1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129.

Molecular Formula	C₁₅H₁₂FN₃S
Molecular Weight	285.34