2394874-60-1

2394874-60-1 structure

2394874-60-1 structure

Name: Axl/Mer/CSF1R-IN-1
Chemical Name: Axl/Mer/CSF1R-IN-1
CAS Number: 2394874-60-1
Molecular Formula: C₂₅H₂₄F₃N₅O₅
Molecular Weight: 531.48
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2023-03-30 19:07:56
Modify Date: 2023-03-30 19:07:56
Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].

Name	Axl/Mer/CSF1R-IN-1

Description	Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms
Target	Kd: <0.1 μM (Axl, Mer, CSF1R)[1]
In Vitro	Axl/Mer-IN-1 (Compound 1) 抑制细胞 Axl 活性，通过 H1299 Elisa 法测得的IC50 为 <0.5 μM。Axl/Mer-IN-1 抑制细胞 CSF1R 活性，通过 THP-1 Elisa 法和 M-NFS-60 活力法测得的 IC50 分别为 <0.5 μM 和 <1.0 μM[1]。
References	[1]. Kiyean NAM, et al. Quinoline derivatives as inhibitors of axl/mer rtk and csf1r. Patent WO2019229251A1.

Molecular Formula	C₂₅H₂₄F₃N₅O₅
Molecular Weight	531.48