Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2394874-60-1

2394874-60-1 structure

2394874-60-1 structure

Name: Axl/Mer/CSF1R-IN-1
Chemical Name: Axl/Mer/CSF1R-IN-1
CAS Number: 2394874-60-1
Molecular Formula: C₂₅H₂₄F₃N₅O₅
Molecular Weight: 531.48
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2023-03-30 19:07:56
Modify Date: 2024-09-25 11:51:48
Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].

Name	Axl/Mer/CSF1R-IN-1

Description	Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms
Target	Kd: <0.1 μM (Axl, Mer, CSF1R)[1]
In Vitro	Axl/Mer-IN-1 (Compound 1) 抑制细胞 Axl 活性，通过 H1299 Elisa 法测得的IC50 为 <0.5 μM。Axl/Mer-IN-1 抑制细胞 CSF1R 活性，通过 THP-1 Elisa 法和 M-NFS-60 活力法测得的 IC50 分别为 <0.5 μM 和 <1.0 μM[1]。
References	[1]. Kiyean NAM, et al. Quinoline derivatives as inhibitors of axl/mer rtk and csf1r. Patent WO2019229251A1.

Molecular Formula	C₂₅H₂₄F₃N₅O₅
Molecular Weight	531.48

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.