Axl/Mer/CSF1R-IN-1
Modify Date: 2025-09-21 15:11:28
Axl/Mer/CSF1R-IN-1 structure
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Common Name | Axl/Mer/CSF1R-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2394874-60-1 | Molecular Weight | 531.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H24F3N5O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Axl/Mer/CSF1R-IN-1Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1]. |
| Name | Axl/Mer/CSF1R-IN-1 |
|---|
| Description | Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: <0.1 μM (Axl, Mer, CSF1R)[1] |
| In Vitro | Axl/Mer-IN-1 (Compound 1) 抑制细胞 Axl 活性，通过 H1299 Elisa 法测得的IC50 为 <0.5 μM。Axl/Mer-IN-1 抑制细胞 CSF1R 活性，通过 THP-1 Elisa 法和 M-NFS-60 活力法测得的 IC50 分别为 <0.5 μM 和 <1.0 μM[1]。 |
| References |
| Molecular Formula | C25H24F3N5O5 |
|---|---|
| Molecular Weight | 531.48 |
| InChIKey | CECCRXOJUSBPSD-UHFFFAOYSA-N |
| SMILES | CCn1nc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)c(OCC(F)(F)F)c1C |