Axl/Mer/CSF1R-IN-1

Modify Date: 2024-09-25 11:51:48

Axl/Mer/CSF1R-IN-1 Structure
Axl/Mer/CSF1R-IN-1 structure
Common Name Axl/Mer/CSF1R-IN-1
CAS Number 2394874-60-1 Molecular Weight 531.48
Density N/A Boiling Point N/A
Molecular Formula C25H24F3N5O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Axl/Mer/CSF1R-IN-1


Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].

 Names

Name Axl/Mer/CSF1R-IN-1

 Axl/Mer/CSF1R-IN-1 Biological Activity

Description Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].
Related Catalog
Target

Kd: <0.1 μM (Axl, Mer, CSF1R)[1]

In Vitro Axl/Mer-IN-1 (Compound 1) 抑制细胞 Axl 活性,通过 H1299 Elisa 法测得的IC50 为 <0.5 μM。Axl/Mer-IN-1 抑制细胞 CSF1R 活性,通过 THP-1 Elisa 法和 M-NFS-60 活力法测得的 IC50 分别为 <0.5 μM 和 <1.0 μM[1]。
References

[1]. Kiyean NAM, et al. Quinoline derivatives as inhibitors of axl/mer rtk and csf1r. Patent WO2019229251A1.

 Chemical & Physical Properties

Molecular Formula C25H24F3N5O5
Molecular Weight 531.48
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