2143586-17-6

2143586-17-6 structure

Name: Cavα2δ1&NET-IN-2
Chemical Name: Cavα2δ1&NET-IN-2
CAS Number: 2143586-17-6
Molecular Formula: C₂₂H₂₆N₆O₂S
Molecular Weight: 438.55
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2023-04-05 10:50:20
Modify Date: 2024-04-11 15:45:41
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1].

Name	Cavα2δ1&NET-IN-2

Description	Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter
Target	Cavα2δ1: 112 nM (Ki); NET: 383 nM (Ki), 67 nM (IC50).
References	[1]. Díaz JL, et al. Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter. J Med Chem. 2021 Feb 25;64(4):2167-2185.

Molecular Formula	C₂₂H₂₆N₆O₂S
Molecular Weight	438.55