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2243689-84-9

2243689-84-9 structure

2243689-84-9 structure

Name: DM-CO-(CH2)5-SMe
Chemical Name: DM-CO-(CH2)5-SMe
CAS Number: 2243689-84-9
Molecular Formula: C₃₉H₅₆ClN₃O₁₀S
Molecular Weight: 794.39
Catalog: Research Areas Cancer
Create Date: 2023-04-03 21:20:09
Modify Date: 2025-08-25 16:49:25
DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells[1].

Name	DM-CO-(CH2)5-SMe

Description	DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	DM-CO-(CH2)5-SMe (0.00008-30 nM；5 d) 抑制 H1703、H1975、COLO704 和 Colo720E 细胞的活性，IC50 值分别为 2.27 pM、0.893 pM、3.04 pM 和 3 pM[1]。
References	[1]. Widdison, et al. Preparation of maytansinoid derivatives with self-immolative peptide linkers and their conjugates as antitumor agents. World Intellectual Property Organization. WO2018160539.

Molecular Formula	C₃₉H₅₆ClN₃O₁₀S
Molecular Weight	794.39

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