2446664-72-6

2446664-72-6 structure

2446664-72-6 structure

Name: FGFR3-IN-5
Chemical Name: FGFR3-IN-5
CAS Number: 2446664-72-6
Molecular Formula: C₂₄H₂₄FN₇O₃
Molecular Weight: 477.49
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2023-05-19 11:44:34
Modify Date: 2024-04-03 11:12:36
FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].

Name	FGFR3-IN-5

Description	FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR3:3 nM (IC50) FGFR2:44 nM (IC50) FGFR1:289 nM (IC50)
In Vitro	FGFR3-IN-5 (compound 37; 5 mM; 1 h; HEK-293 细胞) 抑制 FGFR 磷酸化，对 FGFR3 和 FGFR1 的 IC50 值分别为8 nM 和 59 nM[1]。
References	[1]. James FB, et, al. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases. WO2020131627.

Molecular Formula	C₂₄H₂₄FN₇O₃
Molecular Weight	477.49