FGFR3-IN-5

Modify Date: 2024-04-03 11:12:36

FGFR3-IN-5 Structure
FGFR3-IN-5 structure
Common Name FGFR3-IN-5
CAS Number 2446664-72-6 Molecular Weight 477.49
Density N/A Boiling Point N/A
Molecular Formula C24H24FN7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FGFR3-IN-5


FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].

 Names

Name FGFR3-IN-5

 FGFR3-IN-5 Biological Activity

Description FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].
Related Catalog
Target

FGFR3:3 nM (IC50)

FGFR2:44 nM (IC50)

FGFR1:289 nM (IC50)

In Vitro FGFR3-IN-5 (compound 37; 5 mM; 1 h; HEK-293 细胞) 抑制 FGFR 磷酸化,对 FGFR3 和 FGFR1 的 IC50 值分别为8 nM 和 59 nM[1]。
References

[1]. James FB, et, al. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases. WO2020131627.

 Chemical & Physical Properties

Molecular Formula C24H24FN7O3
Molecular Weight 477.49
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