2408840-41-3

2408840-41-3 structure

Name: Imlunestrant tosylate
Chemical Name: Imlunestrant tosylate
CAS Number: 2408840-41-3
Molecular Formula: C₃₆H₃₂F₄N₂O₆S
Molecular Weight: 696.71
Catalog: Research Areas Cancer
Create Date: 2023-05-06 16:21:13
Modify Date: 2025-09-19 20:10:28
Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].

Name	Imlunestrant tosylate

Description	Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
In Vitro	LY3484356 显示出良好药代动力学 (PK) 特性，包括在 ESR1 突变体中的抗肿瘤活性[1]。
References	[1]. Komal L. Jhaveri, et al. A first-in-human phase 1a/b trial of LY3484356, an oral selective estrogen receptor (ER) degrader (SERD) in ER+ advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Results from the EMBER study. 2021 ASCO Annual Meeting I. [2]. Cristina Hernando, et al. Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective. Int. J. Mol. Sci. 2021, 22(15), 7812.

Molecular Formula	C₃₆H₃₂F₄N₂O₆S
Molecular Weight	696.71