Imlunestrant tosylate

Modify Date: 2024-01-11 18:35:44

Imlunestrant tosylate Structure
Imlunestrant tosylate structure
Common Name Imlunestrant tosylate
CAS Number 2408840-41-3 Molecular Weight 696.71
Density N/A Boiling Point N/A
Molecular Formula C36H32F4N2O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Imlunestrant tosylate


Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].

 Names

Name Imlunestrant tosylate

 Imlunestrant tosylate Biological Activity

Description Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].
Related Catalog
In Vitro LY3484356 显示出良好药代动力学 (PK) 特性,包括在 ESR1 突变体中的抗肿瘤活性[1]。
References

[1]. Komal L. Jhaveri, et al. A first-in-human phase 1a/b trial of LY3484356, an oral selective estrogen receptor (ER) degrader (SERD) in ER+ advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Results from the EMBER study. 2021 ASCO Annual Meeting I.

[2]. Cristina Hernando, et al. Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective. Int. J. Mol. Sci. 2021, 22(15), 7812.

 Chemical & Physical Properties

Molecular Formula C36H32F4N2O6S
Molecular Weight 696.71