937820-89-8
937820-89-8 structure
- Name: JC2-11
- Chemical Name: JC2-11
- CAS Number: 937820-89-8
- Molecular Formula: C17H15FO4
- Molecular Weight: 302.30
- Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
- Create Date: 2023-04-29 19:51:52
- Modify Date: 2024-09-19 12:28:51
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JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1].
| Name | JC2-11 |
|---|
| Description | JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1]. |
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| Related Catalog | |
| Target |
NLRP3 inflammasome |
| In Vivo | JC2-11 (250 μg/鼠；腹腔注射；单剂量) 显著抑制了 C57BL/6 小鼠模型中非典型 (NC) 炎症小体中 caspase-1 (p20) 和 IL-1β 的释放，弱化了 NC 炎症小体的激活[1]。 Animal Model: C57BL/6 mice (8 weeks, female)[1]. Dosage: 250 μg/mouse. Administration: Intraperitoneal injection; single dose. Result: Exhibited inhibitory effect on NC inflammatory body. |
| References |
| Molecular Formula | C17H15FO4 |
|---|---|
| Molecular Weight | 302.30 |