2832887-40-6

2832887-40-6 structure

Name: M5N36
Chemical Name: M5N36
CAS Number: 2832887-40-6
Molecular Formula: C₂₀H₁₆ClN₅O₃
Molecular Weight: 409.83
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2023-04-21 10:29:02
Modify Date: 2024-04-06 09:39:18
M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1].

Name	M5N36

Description	M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Target	IC50: 0.15 µM (Cdc25A); 0.19 µM (Cdc25B); 0.06 µM (Cdc25C)[1]
In Vitro	M5N36 (5, 10 µM; 24 h) 增加 MDA-MB-231 细胞中 p-CDK1 和 p-CDK2 的表达[1]。 Cell Proliferation Assay[1] Cell Line: Eca-109, HepG2, MCF-TAM, MDA-MB-231, Raji, SGC-7901, SW-620, HUVEC cells Concentration: Incubation Time: Result: Showed anti-proliferative activity with IC50s of 2.88, 3.57, 10.00, 2.00, 1.20, 6.03, 3.39, 2.40 µM for Eca-109, HepG2, MCF-TAM, MDA-MB-231, Raji, SGC-7901, SW-620, HUVEC cells, respectively. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5, 10 µM Incubation Time: 24 h Result: Increased the expression of Cdc25A, Cdc25B, increased the expression of p-CDK1 and p-CDK2.
References	[1]. Tao Y, et al. Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries. Bioorg Chem. 2021 Oct;115:105254.

Molecular Formula	C₂₀H₁₆ClN₅O₃
Molecular Weight	409.83