2878360-80-4
2878360-80-4 structure
- Name: MCT1-IN-3
- Chemical Name: MCT1-IN-3
- CAS Number: 2878360-80-4
- Molecular Formula: C22H19N3O4
- Molecular Weight: 389.40
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Monocarboxylate Transporter
- Create Date: 2023-04-06 16:24:00
- Modify Date: 2024-01-12 18:57:08
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MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer[1].
| Name | MCT1-IN-3 |
|---|
| Description | MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
IC50: 81.0 nM (MCT1)[1] GI50: 20 μM (A-549); 15.1 μM (MCF-7)[1] |
| In Vitro | MCT1-IN-3 (compound 24) 对 MCT1 具有抑制活性，IC50 值为 81.0 nM[1]。 MCT1-IN-3 对表达 MCT1 的癌细胞系 A-549 和 MCF-7 具有很强的抗增殖活性，GI50 值分别为 20 μM 和 15.1 μM[1]< /sup>. MCT1-IN-3（5 μM；24 h）导致癌细胞周期停滞和细胞凋亡[1]。 MCT1-IN-3（1.0、2.0、3.5 和 5.0 μM）显示可使这些癌细胞对抗肿瘤药物敏感[1]。 MCT1-IN-3 还对多药转运蛋白 ABCB1 具有显著的抑制作用，并显示可逆转 ABCB1 介导的多药耐药性 (MDR) [1]。 Cell Cycle Analysis[1] Cell Line: A-549 cells Concentration: 5 μM Incubation Time: 24 h Result: Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase. Apoptosis Analysis[1] Cell Line: A-549 cells Concentration: 5 μM Incubation Time: 24 h Result: Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%. |
| References |
| Molecular Formula | C22H19N3O4 |
|---|---|
| Molecular Weight | 389.40 |