1917350-09-4
1917350-09-4 structure
- Name: MDM2-p53-IN-16
- Chemical Name: MDM2-p53-IN-16
- CAS Number: 1917350-09-4
- Molecular Formula: C32H33N3O5
- Molecular Weight: 539.62
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2023-04-17 20:32:53
- Modify Date: 2024-01-14 19:47:10
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MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research[1].
| Name | MDM2-p53-IN-16 |
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| Description | MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research[1]. |
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| Related Catalog | |
| In Vitro | MDM2-p53-IN-16 (0.01 nM-100 μM；1 小时) 解离 MDM2-p53 相互作用，IC50 值为 4.3 nM[1]。 MDM2-p53-IN-16 (1 µM；8 小时) 显著增加多形性成胶质细胞瘤细胞中 p53 的水平[1]。 MDM2-p53-IN-16 (1 µM；6 小时) 增加 p53 靶基因 MDM2、PUMA 和 p21 在 U87MG 细胞中的 mRNA 水平[1]。 MDM2-p53-IN-16 显示出结合移位蛋白 (TSPO) 的能力，Ki 值为 87.2 nM[1]。 MDM2-p53-IN-16 (1 µM；24 小时) 诱导 U87MG 细胞早期和晚期凋亡，和细胞周期阻滞[1]。 MDM2-p53-IN-16 (1-10000 nM；48 小时) 对 U87MG 和野生型 p53 U343MG 细胞具有抗增殖活性，IC50 值分别为 1.2 和 1.6 μM[1]。 Cell Proliferation Assay[1] Cell Line: U87MG, U343MG and T98G cell lines Concentration: 1-10000 nM Incubation Time: 48 hours Result: Inhibited cell proliferation of U87MG, U343MG and T98G cells. Apoptosis Analysis[1] Cell Line: U87MG cell line Concentration: 1 µM Incubation Time: 24 hours Result: Induced cell apoptosis of U87MG cells. Cell Cycle Analysis[1] Cell Line: U87MG, U343MG and T98G cell lines Concentration: 1-10000 nM Incubation Time: 48 hours Result: Induced cell cycle arrest progression in the G2/M-phase of U87MG cells. |
| References |
| Molecular Formula | C32H33N3O5 |
|---|---|
| Molecular Weight | 539.62 |