2648041-72-7

2648041-72-7 structure

2648041-72-7 structure

Name: MODAG-001
Chemical Name: MODAG-001
CAS Number: 2648041-72-7
Molecular Formula: C₁₆H₁₅BrN₄
Molecular Weight: 343.22
Catalog: Research Areas Neurological Disease
Create Date: 2023-04-09 12:47:37
Modify Date: 2024-01-02 15:24:32
MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe[1][2][3].

Name	MODAG-001

Description	MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	MODAG-001 shows strong binding affinity to recombinant human α-syn aggregates, but fail to bind real α-syn aggregates in human brain sections[2].
References	[1]. Bousiges O, et al. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. Int J Mol Sci. 2022 Jun 7;23(12):6371. [2]. Bian J, et al. Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands. Eur J Med Chem. 2021 Dec 15;226:113887. [3]. Akasaka T, et al. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679.

Molecular Formula	C₁₆H₁₅BrN₄
Molecular Weight	343.22