2598242-66-9

2598242-66-9 structure

2598242-66-9 structure

Name: NG-497
Chemical Name: NG-497
CAS Number: 2598242-66-9
Molecular Formula: C₁₈H₂₁NO₄
Molecular Weight: 315.36
Catalog: Signaling Pathways Metabolic Enzyme/Protease ATGL
Create Date: 2023-04-14 22:02:45
Modify Date: 2024-01-02 19:13:23
NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research[1].

Name	NG-497

Description	NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> ATGL
In Vitro	NG-497 可选择性地使人和非人灵长类动物 ATGL 失活，但不会使结构和功能相关的脂质水解酶失活，并以剂量依赖性和可逆的方式消除人类脂肪细胞的脂肪分解[1]。 NG-497(40 μM, 80 min)可以减少 HepG2 细胞的脂解依赖性呼吸，并且不会通过脱靶效应损害线粒体功能[1]。
References	[1]. Gernot F Grabner, et al. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. J Am Chem Soc. 2022 Apr 13;144(14):6237-6250.

Molecular Formula	C₁₈H₂₁NO₄
Molecular Weight	315.36