1042780-52-8
1042780-52-8 structure
- Name: PARP10-IN-2
- Chemical Name: PARP10-IN-2
- CAS Number: 1042780-52-8
- Molecular Formula: C14H10N2O2
- Molecular Weight: 238.24
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
- Create Date: 2023-04-05 12:00:46
- Modify Date: 2024-01-14 09:38:23
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PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].
| Name | PARP10-IN-2 |
|---|
| Description | PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
human PARP10:3.64 μM (IC50) human PARP15:11 μM (IC50) human PARP2:27 μM (IC50) human PARP12:>10 μM (IC50) human PARP16:>10 μM (IC50) human PARP1:>100 μM (IC50) human PARP3:>100 μM (IC50) human PARP4:>100 μM (IC50) human TNKS1:>100 μM (IC50) human TNKS2:>100 μM (IC50) human PARP14:>100 μM (IC50) |
| In Vitro | PARP10-IN-2 (化合物 10) 在 HeLa-PARP10 细胞中通过克隆形成测定 (CFA) 的 IC50 为 1-2 μM[1]。 |
| References |
| Molecular Formula | C14H10N2O2 |
|---|---|
| Molecular Weight | 238.24 |