2665734-13-2

2665734-13-2 structure
2665734-13-2 structure
  • Name: PD-1/PD-L1-IN-29
  • Chemical Name: PD-1/PD-L1-IN-29
  • CAS Number: 2665734-13-2
  • Molecular Formula: C26H24N2O6
  • Molecular Weight: 460.48
  • Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
  • Create Date: 2023-04-02 20:53:59
  • Modify Date: 2024-04-06 13:29:12
  • PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity[1].

Name PD-1/PD-L1-IN-29
Description PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity[1].
Related Catalog
In Vitro PD-1/PD-L1-IN-29(S4-1)(10 or 20 μM, 48 h) 可以通过阻断 PD-1/PD-L1 相互作用,恢复 PBMCs 的活化状态,增加 PBMCs 对A375 肿瘤细胞的细胞毒性,而对肿瘤细胞的直接杀伤作用很小[1]。
In Vivo PD-1/PD-L1-IN-29(S4-1)(10 or 25 mg/kg, i.p., 12 days) 在 MC38 结直肠肿瘤小鼠模型中,可以显著抑制肿瘤的生长,低剂量组和高剂量组(10 和 25 mg/kg)均可观察到,且抑制率分别为 65.9% 和 88.8%[1]。
References

[1]. Chengliang Sun, et al. Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment. J Med Chem. 2022 Dec 29.  

Molecular Formula C26H24N2O6
Molecular Weight 460.48