188425-80-1

188425-80-1 structure

Name: st-Ht31
Chemical Name: st-Ht31
CAS Number: 188425-80-1
Molecular Formula: C₁₂₉H₂₁₇N₂₉O₃₉
Molecular Weight: 2798.32
Catalog: Signaling Pathways Cell Cycle/DNA Damage PAK
Create Date: 2023-04-15 18:29:18
Modify Date: 2024-01-12 11:09:35
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage[1][2].

Name	st-Ht31

Description	st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage[1][2].
Related Catalog	Signaling Pathways >> Cytoskeleton >> PAK Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PAK
In Vitro	st-Ht31 (5 µM; 2 h) 增强 BHK 细胞和 RAW 巨噬细胞中的胆固醇/磷脂流出[1]。 st-Ht31 (10µM; 24 h) 逆转泡沫细胞形成并恢复巨噬细胞的代谢健康[1]。st-Ht31 (20 µM; 20 min) 消除 HEK293T 细胞中 PMA 诱导的 ERK1/2 激活的 cAMP 抑制[2]。 Western Blot Analysis[2] Cell Line: HEK293T cells Concentration: 20 µM Incubation Time: 20 min Result: Abolished the cAMP inhibition of PMA-induced ERK1/2 activation.
References	[1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8. [2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.

Molecular Formula	C₁₂₉H₂₁₇N₂₉O₃₉
Molecular Weight	2798.32