2839639-94-8

2839639-94-8 structure

Name: STING modulator-3
Chemical Name: STING modulator-3
CAS Number: 2839639-94-8
Molecular Formula: C₁₈H₁₇N₉O
Molecular Weight: 375.39
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2023-04-05 16:46:43
Modify Date: 2024-01-02 16:10:46
STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells[1].

Name	STING modulator-3

Description	STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
In Vitro	STING modulator-3 (AIP01) (10 μM；3 h，24 h) 分别不影响处理 THP-1 细胞 3 h 时，IRF-3 的磷酸化或是处理 24 h 时，对 TNF-β 的诱导[1]。
References	[1]. Gajiwala KS, et al. Imidazole derivatives as STING modulators and their preparation, pharmaceutical compositions and use in the treatment of cancer: World Intellectual Property Organization, WO2022195462. 2022-09-22.

Molecular Formula	C₁₈H₁₇N₉O
Molecular Weight	375.39