2411389-65-4

2411389-65-4 structure
2411389-65-4 structure
  • Name: Thalidomide-O-C6-azide
  • Chemical Name: Thalidomide-O-C6-azide
  • CAS Number: 2411389-65-4
  • Molecular Formula: C19H21N5O5
  • Molecular Weight: 399.40
  • Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
  • Create Date: 2023-05-24 07:02:00
  • Modify Date: 2024-01-20 11:35:35
  • Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology[1].

Name Thalidomide-O-C6-azide
Description Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
In Vitro PROTAC 包含两个不同的配体,通过一个接头连接;一个是 E3 泛素连接酶的配体,另一个是靶蛋白的配体。 PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[2]。
References

[1]. Chen P, et al. α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship. Bioorg Chem. 2021 Nov;116:105295.  

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-996.  

Molecular Formula C19H21N5O5
Molecular Weight 399.40