2411389-65-4

2411389-65-4 structure

Name: Thalidomide-O-C6-azide
Chemical Name: Thalidomide-O-C6-azide
CAS Number: 2411389-65-4
Molecular Formula: C₁₉H₂₁N₅O₅
Molecular Weight: 399.40
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2023-05-24 07:02:00
Modify Date: 2024-01-20 11:35:35
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology[1].

Name	Thalidomide-O-C6-azide

Description	Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
In Vitro	PROTAC 包含两个不同的配体，通过一个接头连接；一个是 E3 泛素连接酶的配体，另一个是靶蛋白的配体。 PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[2]。
References	[1]. Chen P, et al. α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship. Bioorg Chem. 2021 Nov;116:105295. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-996.

Molecular Formula	C₁₉H₂₁N₅O₅
Molecular Weight	399.40