118675-87-9
118675-87-9 structure
- Name: Thymidine 3',5'-diphosphate tetrasodium
- Chemical Name: Thymidine 3',5'-diphosphate tetrasodium
- CAS Number: 118675-87-9
- Molecular Formula: C10H12N2Na4O11P2
- Molecular Weight: 490.12
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-04-15 18:45:25
- Modify Date: 2025-09-07 10:03:19
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Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) tetrasodium is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit). Thymidine 3',5'-diphosphate tetrasodium exhibits anti-tumor efficacy in vivo[1].
| Name | Thymidine 3',5'-diphosphate tetrasodium |
|---|
| Description | Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) tetrasodium is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit). Thymidine 3',5'-diphosphate tetrasodium exhibits anti-tumor efficacy in vivo[1]. |
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| Related Catalog | |
| Target |
Staphylococcal nuclease and tudor domain containing 1, SND1[1] |
| In Vitro | Thymidine 3',5'-diphosphate tetrasodium (200 µM；18 h) 通过抑制葡萄球菌核酸酶和含有 1 的都铎结构域 (SND1) 酶活性显著降低 WT 和 Alb/SND1 (特异性过表达 SND1 转基因小鼠) 肝细胞中 p65 表达水平和 p65 核易位。Thymidine 3',5'-diphosphate tetrasodium 抑制了 WT 和 Alb/SND1 肝细胞的球形形成[1]。 |
| In Vivo | Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg 或 1.6 mg/kg；腹腔注射或静脉注射；每周两次持续四周) 显著抑制 WT B6/CBA 小鼠中人肝癌的异种移植[1]。 Thymidine 3',5'-diphosphate tetrasodium (0.8, 0.16 和 0.32 mg/kg；皮下注射；每周两次持续四周) 抑制成年雄性 NSG 小鼠中肿瘤增殖、炎症反应和肿瘤起源细胞 (TIC) 标志物的表达。Thymidine 3',5'-diphosphate tetrasodium 上调了凋亡和选择性肿瘤抑制基因的表达[1]。 |
| References |
| Molecular Formula | C10H12N2Na4O11P2 |
|---|---|
| Molecular Weight | 490.12 |