Shanghai Nianxing Industrial Co., Ltd
China
Product Name: WF-536
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: WF-536
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

539857-64-2

539857-64-2 structure

539857-64-2 structure

Name: WF-536
Chemical Name: WF-536
CAS Number: 539857-64-2
Molecular Formula: C₁₄H₁₆ClN₃O
Molecular Weight: 277.75
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2023-05-05 19:59:10
Modify Date: 2024-01-10 09:47:33
WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1].

Name	WF-536

Description	WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
In Vitro	WF-536（1、3、10、30、100 μM）抑制 LLC 细胞的侵袭和迁移以及内皮细胞在 Matrigel 上的侵袭、迁移和毛细管样管的形成，在这两种细胞类型下均无细胞毒性或抗增殖作用[1]。 Cell Migration Assay [1] Cell Line: LLC cells, Human umbilical vein endothelial cells Concentration: 1, 3, 10, 30 μM Incubation Time: 6 h (tumor cells), 4 h (endothelial cells) Result: Significantly inhibited LLC-cell migration, with inhibitory rates of 23% and 44% at 10 and 30 μM, respectively. Cell Invasion Assay[1] Cell Line: LLC cells, Human umbilical vein endothelial cells Concentration: 1, 3, 10, 30 μM Incubation Time: 18 h Result: Showed significant and concentration-dependent inhibition of LLC-cell invasion. Cell Proliferation Assay[1] Cell Line: LLC cells, Human umbilical vein endothelial cells Concentration: 1, 30, 100 μM Incubation Time: 24, 48, 72, and 96 h Result: Showed no significant effect at 1-30 μM on the proliferation up to 96 h incubation, although the proliferation was decreased at 100 μM over 48 h.
In Vivo	WF-536（口服；0.3-3 mg/kg/天；持续 28 天）抑制小鼠 Lewis 肺癌 (LLC) 转移和 LLC 诱导的血管生成[1]。 Animal Model: C57BL/6 mice (male, 6-week old)[1] Dosage: 0.3, 1, 3 mg/kg Administration: Oral; daily; for 28 days Result: Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg).
References	[1]. Nakajima, Masahide et al. Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions. European journal of pharmacology vol. 459,2-3 (2003): 113-20.

Molecular Formula	C₁₄H₁₆ClN₃O
Molecular Weight	277.75

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.