2305045-76-3

2305045-76-3 structure

2305045-76-3 structure

Name: XL 188
Chemical Name: XL 188
CAS Number: 2305045-76-3
Molecular Formula: C₃₂H₄₂N₆O₄
Molecular Weight: 574.71
Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
Create Date: 2023-05-06 07:13:25
Modify Date: 2024-04-03 01:24:55
XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer[1].

Name	XL 188

Description	XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
In Vitro	Xl 188 (1-20 μm; 16 h; MCF7 细胞) 促进 USP7 依赖性 HDM2 的丢失和 p53 和 p21 的增加[1]。 Western Blot Analysis[1] Cell Line: MCF7 cells Concentration: 1, 5, 10, and 20μM Incubation Time: 16 hours Result: Had the loss of HDM2 accompanied by an increase in downstream tumor suppressors p21 and p53.
References	[1]. Stolte B, et, al. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 Aug 6;215(8):2137-2155.

Molecular Formula	C₃₂H₄₂N₆O₄
Molecular Weight	574.71