2449086-91-1

2449086-91-1 structure
2449086-91-1 structure
  • Name: Ormutivimab
  • Chemical Name: Ormutivimab
  • CAS Number: 2449086-91-1
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Research Areas Infection
  • Create Date: 2023-07-09 10:55:01
  • Modify Date: 2025-08-25 15:18:46
  • Ormutivimab (rhRIG) is a recombinant human monoclonal antibody, targeting rabies virus. Ormutivimab neutralizes a variety of rabies virus strains. Ormutivimab exhibits potent potency against rabies post-exposure prophylaxis (PEP) model[1][2].

Name Ormutivimab
Description Ormutivimab (rhRIG) is a recombinant human monoclonal antibody, targeting rabies virus. Ormutivimab neutralizes a variety of rabies virus strains. Ormutivimab exhibits potent potency against rabies post-exposure prophylaxis (PEP) model[1][2].
Related Catalog
In Vivo Ormutivimab (20 IU/kg;肌肉注射;单剂量) 保护比格犬免受 RABV BD06 的致命攻击[1]。 Ormutivimab (20 IU/kg、100 IU/kg;肌注;单剂量) 保护受攻击的 Kunming 小鼠免受各种狂犬病病毒的侵害[1]。 Animal Model: Balb/c mice challenge model with rabies virus[1] Dosage: 20 IU/kg, 100 IU/kg Administration: Intramuscular injection; single dose after 4 hr after infection Result: Protected mice from rabies CVS-24 and GZ-1 isolates at a comparable rate (90%) to that of HRIG, human antirabies immune globulin.
References

[1]. Zhai LL, et al. Efficacy of ormutivimab, a novel recombinant human anti-rabies monoclonal antibody, in post-exposure prophylaxis animal models. Travel Med Infect Dis. 2022 Mar-Apr;46:102267.  

[2]. Zhang J, et al. Population Pharmacodynamic Analyses of Human Anti-Rabies Virus Monoclonal Antibody (Ormutivimab) in Healthy Adult Subjects. Vaccines (Basel). 2022 Jul 29;10(8):1218.  

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