960210-97-3

960210-97-3 structure

Name: PM050489
Chemical Name: PM050489
CAS Number: 960210-97-3
Molecular Formula: C₃₁H₄₄ClN₃O₇
Molecular Weight: 606.15
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2023-08-03 16:53:05
Modify Date: 2024-04-08 14:17:57
PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2].

Name	PM050489

Description	PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	Mitosis[1]
In Vitro	PM050489 抑制 HT-29、A-549 和 MDA-MB-231 细胞的活力，GI50 分别为 0.46 nM、0.38 nM 和 0.45 nM[1]。 PM050489 (0.01 nM 和 0.1 nM；24 h) 破坏 A549 细胞中微管网络和有丝分裂纺锤体的形态[2]。 PM050489 (0.01、0.1、1 和 10 nM) 以剂量依赖性方式在 A549 细胞中抑制微管蛋白的聚合[2]。 Cell Cycle Analysis[2] Cell Line: A549 cells. Concentration: 0.25 nM. Incubation Time: 20 h. Result: Induced A549 cell cycle arrest in G2/M phase.
References	[1]. Martín MJ, et al. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J Am Chem Soc. 2013 Jul 10;135(27):10164-71. [2]. Pera B, et al. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.

Molecular Formula	C₃₁H₄₄ClN₃O₇
Molecular Weight	606.15