2408723-10-2

2408723-10-2 structure

Name: STING agonist-25
Chemical Name: STING agonist-25
CAS Number: 2408723-10-2
Molecular Formula: C₃₆H₄₁N₁₃O₆
Molecular Weight: 751.79
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2023-04-27 13:37:13
Modify Date: 2024-01-12 19:28:01
STING agonist-25 (CF505) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

Name	STING agonist-25

Description	STING agonist-25 (CF505) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> STING
In Vitro	STING agonist-25 (10 μM；3 小时或 5 小时) 处理 THP-1 细胞 3 小时后，增加磷酸化 STING、TBK1 和 IRF3 的水平；处理 THP-1 细胞 5 小时后，增加 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15 和 CCL-5 的含量[1]。
References	[1]. Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287.

Molecular Formula	C₃₆H₄₁N₁₃O₆
Molecular Weight	751.79