184539-13-7
184539-13-7 structure
- Name: Teicoplanin sodium
- Chemical Name: Teicoplanin sodium
- CAS Number: 184539-13-7
- Molecular Formula:
- Molecular Weight: 1564.3-1907.7
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2023-06-11 21:16:40
- Modify Date: 2024-01-09 17:21:29
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Teicoplanin sodium (Antibiotic MDL-507 sodium) is a potent lipoglycopeptide antibiotic. Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity[1][2].
| Name | Teicoplanin sodium |
|---|
| Description | Teicoplanin sodium (Antibiotic MDL-507 sodium) is a potent lipoglycopeptide antibiotic. Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity[1][2]. |
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| Related Catalog | |
| Target |
MRSA[2] |
| In Vitro | Teicoplanin sodium 显示出抗病毒活性，对 HEK293T 细胞中的 HIV-luc/SARS-CoV-S 病毒、A549 细胞中的 2019-nCoV-Spike-病毒和Vero E6 细胞中的 SARS-CoV-2 病毒的 IC50 值分别为 0.39、1.66、15.7 µM[1]。 Teicoplanin sodium 可抑制人 CEM 细胞培养物中的 HIV-1 病毒，EC50 值为 17 µM[1]。 其机制是通过 Teicoplanin sodium 亲脂部分与酶的相互作用抑制抑制组织蛋白酶 L 活性并阻止 SARS-CoV 从晚期内体释放[1]。 Teicoplanin sodium 表现出抗 MRSA 活性，对 MRSA ATCC 43300 的 MIC 值为 0.5 mg/L[2]。 |
| In Vivo | Teicoplanin sodium (10, 30 mg/kg; i.v.) 在小鼠 MRSA 大腿感染模型中表现出剂量依赖性的总细菌密度下降[2]。 Animal Model: 20-30 g, Male CD1 mice (2 * 106 cfu/mL MRSA (43 300) 50 µL; murine thigh infection model)[2] Dosage: 10, 30 mg/kg Administration: I.v.; once every 12 h Result: Showed a dose-dependent decline in the total bacterial density with the total bactericidal effect was achieved with dosages of ≥10 mg/kg/day and suppression of resistance with dosages ≥30 mg/kg/day. |
| References |
| Molecular Weight | 1564.3-1907.7 |
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