28728-55-4
28728-55-4 structure
- Name: Hexadimethrine bromide
- Chemical Name: Sequa-brene
- CAS Number: 28728-55-4
- Molecular Formula: C15H36Br2N2
- Molecular Weight: 404.27
- Catalog: Research Areas Cancer
- Create Date: 2018-03-09 08:00:00
- Modify Date: 2026-07-03 11:26:59
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Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction.
| Name | Sequa-brene |
|---|---|
| Synonyms |
POLYBRENE
HEXADIMETHRIN BROMIDE, FOR PROTEIN SEQUE NCE ANALYSIS Hexadimethrine bromide,inhibit,Polybrene,Hexadimethrine,Inhibitor HEXADIMETHRINE BROMIDE, >= Hexadimethrine bromide (1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) 1,5-DIMETHYL-1,5-DIAZAUNDECAMETHYLENE POLYMETHOBROMIDE Hexadimethrine bromide,1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide, Polybrene POLY(N,N,N',N'-TETRAMETHYL-N-TRIMETHYLENEHEXAMETHYLENEDIAMMONIUM DIBROMIDE) POLYBRENE (R)) Sequa-brene,Hexadimethrine bromide, Polybrene HEXADIMETHRINE BROMIDE Poly[(dimethyliminio)-1,3-propanediyl(dimethyliminio)-1,6-hexanediyl bromide (1:2) 6,3-ionenebromide Hexadimethrine bromide (Synonyms: 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) SEQUA-BRENE(TM) Hexadimethrine bromide,Polybrene poly((dimethyliminio)hexamethylene(dimethylimino)trimethylenedibromide) HEXADIMETHRIN BROMIDE 6,3-ionene Poly(dimethyliminio)-1,3-propanediyl(dimethyliminio)-1,6-hexanediyl dibromide sequa-brene 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide,Polybrene MFCD00133397 |
| Description | Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction. |
|---|---|
| Related Catalog | |
| In Vitro | Hexadimethrine bromide inhibits human mesenchymal stem cell proliferation during lentiviral transduction. Hexadimethrine bromide is considered non-toxic at low concentrations, but has been found to negatively affect cell proliferation in some cell types at concentrations greater than 10 µg/mL. Trypsinized cells exposed to Hexadimethrine bromide are visibly larger in size when viewed under the microscope[1]. |
| Cell Assay | Trypsinized cells are washed and resuspended in medium at 2×104 cells/mL with or without rhFGF-2 (final concentration=10 ng/mL, PeproTech) and with or without Hexadimethrine bromide at a final Hexadimethrine bromide concentration of 1, 4, or 8 µg/mL. The different conditions are seeded in 96-well plates at 1×103 cells in 50 µL per well in triplicate and cultured at 37°C, 5% CO2. After 6, 9, or 24 hr, the medium is changed and subsequent medium changes occurred every 3-4 days with 50 µL of ± FGF-2 medium (10 ng/mL). Plates are harvested on day 4, 7, 14, and 21 by removing the medium and placing the plates in the -80°C freezer until the day of analysis. The CyQUANT assay is then performed on the wells[1]. |
| References |
| Boiling Point | 209.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C15H36Br2N2 |
| Molecular Weight | 404.27 |
| Flash Point | 73.9ºC |
| Vapour Pressure | 0.202mmHg at 25°C |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| RIDADR | UN 2811 |
| RTECS | TQ2655000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |