2477651-10-6
2477651-10-6 structure
- Name: USP8-IN-3
- Chemical Name: USP8-IN-3
- CAS Number: 2477651-10-6
- Molecular Formula: C18H18F3N5O2S
- Molecular Weight: 425.43
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
- Create Date: 2023-05-20 19:26:37
- Modify Date: 2025-08-25 17:12:02
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USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively[1].
| Name | USP8-IN-3 |
|---|
| Description | USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively[1]. |
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| Related Catalog | |
| Target |
USP8:4.0 μM (IC50) |
| In Vitro | USP8-IN-3 (6.25-100 μM; 15 min) 抑制 USP8 对二聚泛素的剪切活性[1]。 Western Blot Analysis[1] Cell Line: / Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM Incubation Time: 15 min; added Di-Ub substrate for another 1 h Result: Decreased the cleaved diubiquitin level. |
| References |
| Molecular Formula | C18H18F3N5O2S |
|---|---|
| Molecular Weight | 425.43 |