2675490-72-7
2675490-72-7 structure
- Name: DIZ-3
- Chemical Name: DIZ-3
- CAS Number: 2675490-72-7
- Molecular Formula: C46H44F2N8
- Molecular Weight: 746.89
- Catalog: Signaling Pathways Cell Cycle/DNA Damage G-quadruplex
- Create Date: 2023-05-31 07:43:01
- Modify Date: 2024-02-03 10:53:56
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DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1].
| Name | DIZ-3 |
|---|
| Description | DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1]. |
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| Related Catalog | |
| In Vitro | DIZ-3 (0-40 μM; 24 小时) 抑制 ALT 癌细胞系的增殖[1]。 DIZ-3 (0.6-2.5 μM; 24小时) 诱导 U2OS 细胞周期停滞和细胞凋亡[1]。 DIZ-3 (0.12, 0.25, 0.5 μM; 7 天) 导致 U2OS 细胞集落形成[1]。 DIZ-3 (0.12, 0.25, 0.5 μM; 24小时) 显着抑制 U2OS 细胞的迁移[1]。 Cell Proliferation Assay[1] Cell Line: Human bone osteosarcoma U2OS cells, normal BJ fibroblasts Concentration: 0-40 μM Incubation Time: 24 hours Result: Caused a significant dose-dependent cytotoxic effect on U2OS cancer cells with an IC50 of 2.1 µM. Induced much weaker growth inhibition on normal BJ fibroblasts with an IC50 of 29.3 µM. Apoptosis Analysis[1] Cell Line: U2OS cells Concentration: 0.6, 1.2, 2.5 μM Incubation Time: 24 hours Result: Induced significant apoptosis in U2OS cells (the percentage of apoptotic cells increased from 10.1% to 24.9%). Cell Cycle Analysis[1] Cell Line: U2OS cells Concentration: 0.6, 1.2, 2.5 μM Incubation Time: 24 hours Result: Induced the apparent accumulation of cells in the S phase (increasing from 24.0% to 32.2%) in a dose-dependent manner. |
| References |
| Molecular Formula | C46H44F2N8 |
|---|---|
| Molecular Weight | 746.89 |