DIZ-3
Modify Date: 2025-12-06 15:36:17
DIZ-3 structure
|
Common Name | DIZ-3 | ||
|---|---|---|---|---|
| CAS Number | 2675490-72-7 | Molecular Weight | 746.89 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C46H44F2N8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DIZ-3DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1]. |
| Name | DIZ-3 |
|---|
| Description | DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1]. |
|---|---|
| Related Catalog | |
| In Vitro | DIZ-3 (0-40 μM; 24 小时) 抑制 ALT 癌细胞系的增殖[1]。 DIZ-3 (0.6-2.5 μM; 24小时) 诱导 U2OS 细胞周期停滞和细胞凋亡[1]。 DIZ-3 (0.12, 0.25, 0.5 μM; 7 天) 导致 U2OS 细胞集落形成[1]。 DIZ-3 (0.12, 0.25, 0.5 μM; 24小时) 显着抑制 U2OS 细胞的迁移[1]。 Cell Proliferation Assay[1] Cell Line: Human bone osteosarcoma U2OS cells, normal BJ fibroblasts Concentration: 0-40 μM Incubation Time: 24 hours Result: Caused a significant dose-dependent cytotoxic effect on U2OS cancer cells with an IC50 of 2.1 µM. Induced much weaker growth inhibition on normal BJ fibroblasts with an IC50 of 29.3 µM. Apoptosis Analysis[1] Cell Line: U2OS cells Concentration: 0.6, 1.2, 2.5 μM Incubation Time: 24 hours Result: Induced significant apoptosis in U2OS cells (the percentage of apoptotic cells increased from 10.1% to 24.9%). Cell Cycle Analysis[1] Cell Line: U2OS cells Concentration: 0.6, 1.2, 2.5 μM Incubation Time: 24 hours Result: Induced the apparent accumulation of cells in the S phase (increasing from 24.0% to 32.2%) in a dose-dependent manner. |
| References |
| Molecular Formula | C46H44F2N8 |
|---|---|
| Molecular Weight | 746.89 |
| InChIKey | NHADRDLRJIYBGX-UHFFFAOYSA-N |
| SMILES | CN1CCN(c2ccc(-c3[nH]c(-c4ccc(-c5nc(-c6ccc(F)cc6)c(-c6ccc(N7CCN(C)CC7)cc6)[nH]5)cc4)nc3-c3ccc(F)cc3)cc2)CC1 |