2396691-28-2

2396691-28-2 structure
2396691-28-2 structure
  • Name: DNMT-IN-1
  • Chemical Name: DNMT-IN-1
  • CAS Number: 2396691-28-2
  • Molecular Formula: C15H9BrN2O6
  • Molecular Weight: 393.15
  • Catalog: Signaling Pathways Epigenetics DNA Methyltransferase
  • Create Date: 2023-06-22 18:25:14
  • Modify Date: 2024-04-11 10:35:27
  • DNMT-IN-1 is a potent DNMT inhibitor with an EC50 value of 3.2 µM. DNMT-IN-1 shows antiproliferative active[1].

Name DNMT-IN-1
Description DNMT-IN-1 is a potent DNMT inhibitor with an EC50 value of 3.2 µM. DNMT-IN-1 shows antiproliferative active[1].
Related Catalog
Target

DNA Methyltransferase:3.2 μM (EC50)

In Vitro DNMT-IN-1 (compound 3b) 具有抗增殖活性,对 KG1、HCT116 细胞的 EC50 分别为 13.0、10.7 µM[1]。 Cell Proliferation Assay[1] Cell Line: KG1, HCT116 cells Concentration: 0-100 µM Incubation Time: 72 h Result: Showed antiproliferative active with EC50s of 13.0, 10.7 µM for KG1, HCT116 cells, respectively.
References

[1]. Pechalrieu D, et al. Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells. Eur J Med Chem. 2020 Jan 15;186:111829.  

Molecular Formula C15H9BrN2O6
Molecular Weight 393.15
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