2494010-63-6
2494010-63-6 structure
- Name: ERK-IN-7
- Chemical Name: ERK-IN-7
- CAS Number: 2494010-63-6
- Molecular Formula: C22H20ClN7O2
- Molecular Weight: 449.89
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2023-05-30 22:41:54
- Modify Date: 2025-08-20 18:21:33
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ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively[1].
| Name | ERK-IN-7 |
|---|
| Description | ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK1:5 nM (IC50) ERK2:7 nM (IC50) |
| In Vitro | ERK-IN-7 (Example 10; 24 h) 抑制 Colo205 增殖，IC50 为 62 nM[1]。 Cell Proliferation Assay[1] Cell Line: Colo205 Concentration: Incubation Time: 24 h Result: Inhibited proliferation with an IC50 of 62 nM. |
| In Vivo | ERK-IN-7 (Example 10; 2 mg/kg; i.g.) 具有良好的药代动力学结果[1] Animal Model: C57 mice[1] Dosage: 2 mg/kg Administration: Intragastric administration (Pharmacokinetic Analysis) Result: Pharmacokinetic parameters[1] Cmax (ng/mL) AUC (ng⋅h/mL) T1/2 (h) MRT (h) CLz/F (mL/min/kg) Vz/F (mL/kg) ERK-IN-7 (Example 10) 1023 3441 3.66 3.47 9.69 3067 |
| References |
| Molecular Formula | C22H20ClN7O2 |
|---|---|
| Molecular Weight | 449.89 |