2570797-85-0
2570797-85-0 structure
- Name: HSGN-94
- Chemical Name: HSGN-94
- CAS Number: 2570797-85-0
- Molecular Formula: C23H23F3N4O4S
- Molecular Weight: 508.51
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2023-07-27 07:52:06
- Modify Date: 2024-01-24 19:29:15
-
HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model[1].
| Name | HSGN-94 |
|---|
| Description | HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model[1]. |
|---|---|
| Related Catalog | |
| In Vitro | HSGN-94（50 μM；30 分钟）直接结合 CDP-二酰基甘油-甘油-3-磷酸-3-磷脂酰转移酶 (PgsA)[1]。 HSGN-94（0.25 μg/mL；2 小时）下调 PgsA 的表达水平，PgsA 是细菌中磷脂合成的必需蛋白质[1]。 HSGN-94（16、32、64 和 128 μg/mL；2 小时）在浓度高达 64 μg/mL 时对 HaCat 细胞没有毒性[1]。 |
| In Vivo | HSGN-94（2%；外用；每天两次，持续 5 天）减少小鼠受感染伤口中的 MRSA USA300，并导致感染模型中的炎症消退[1]。 Animal Model: MRSA murine wound infection model[1] Dosage: 2% Administration: External use; twice daily for 5 days Result: Reduced the levels of the pro-inflammatory cytokines, monocyte chemo attractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) in MRSA USA300 skin lesions. |
| References |
| Molecular Formula | C23H23F3N4O4S |
|---|---|
| Molecular Weight | 508.51 |