Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Leniolisib phosphate
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Leniolisib phosphate
Price: ￥550.0/100mg ￥1100.0/250mg ￥2200.0/1g ￥220.0/10ml
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1354691-97-6

1354691-97-6 structure

1354691-97-6 structure

Name: Leniolisib phosphate
Chemical Name: Leniolisib phosphate
CAS Number: 1354691-97-6
Molecular Formula: C₂₁H₂₈F₃N₆O₆P
Molecular Weight: 548.45
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2023-07-05 13:36:46
Modify Date: 2024-09-23 18:16:58
Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

Name	Leniolisib phosphate

Description	Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology
Target	PI3Kδ:11 nM (IC50) PI3Kα:280 nM (IC50) PI3Kβ:480 nM (IC50) PI3Kγ:2.57 nM (IC50) DNA-PK:880 nM (IC50)
In Vitro	APDS 突变体 p110δ 在细胞系和患者来源的淋巴细胞中的表达导致通路活性增加，以 AKT 或 S6 的磷酸化来衡量。而 Leniolisib phosphate 以浓度依赖性方式抑制该通路活性[1]。
References	[1]. Rao V, et al. Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine: NEJM. ISSN 0028-4793; 1533-4406 [2]. Hoegenauer K, et al. Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2017 Aug 25;8(9):975-980.

Molecular Formula	C₂₁H₂₈F₃N₆O₆P
Molecular Weight	548.45

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