2873460-70-7

2873460-70-7 structure

Name: MC-GGFG-AM-(10Me-11F-Camptothecin)
Chemical Name: MC-GGFG-AM-(10Me-11F-Camptothecin)
CAS Number: 2873460-70-7
Molecular Formula: C₅₁H₅₆FN₉O₁₄
Molecular Weight: 1038.04
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2023-07-08 16:17:12
Modify Date: 2024-01-03 13:43:25
MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].

Name	MC-GGFG-AM-(10Me-11F-Camptothecin)

Description	MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase I
References	[1]. Madera L, et al. ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload[J]. Cancer Research, 2023, 83(7_Supplement): 2658-2658.

Molecular Formula	C₅₁H₅₆FN₉O₁₄
Molecular Weight	1038.04