MC-GGFG-AM-(10Me-11F-Camptothecin)

Modify Date: 2024-01-03 13:43:25

MC-GGFG-AM-(10Me-11F-Camptothecin) Structure
MC-GGFG-AM-(10Me-11F-Camptothecin) structure
 Common Name MC-GGFG-AM-(10Me-11F-Camptothecin)
CAS Number 2873460-70-7 Molecular Weight 1038.04
Density N/A Boiling Point N/A
Molecular Formula C51H56FN9O14 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MC-GGFG-AM-(10Me-11F-Camptothecin)


MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].

 Names

Name MC-GGFG-AM-(10Me-11F-Camptothecin)

 MC-GGFG-AM-(10Me-11F-Camptothecin) Biological Activity

Description MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].
Related Catalog
Target

Topoisomerase I

References

[1]. Madera L, et al. ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload[J]. Cancer Research, 2023, 83(7_Supplement): 2658-2658.

 Chemical & Physical Properties

Molecular Formula C51H56FN9O14
Molecular Weight 1038.04
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Chemsrc provides MC-GGFG-AM-(10Me-11F-Camptothecin)(CAS#:2873460-70-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of MC-GGFG-AM-(10Me-11F-Camptothecin) are included as well.>> amp version: MC-GGFG-AM-(10Me-11F-Camptothecin)

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