150085-21-5
150085-21-5 structure
- Name: S1R agonist 2
- Chemical Name: S1R agonist 2
- CAS Number: 150085-21-5
- Molecular Formula: C21H27NO
- Molecular Weight: 309.45
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2023-05-31 19:11:35
- Modify Date: 2024-01-20 17:31:30
-
S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].
| Name | S1R agonist 2 |
|---|
| Description | S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
Sigma 1 Receptor:1.1 nM (Ki) Sigma 2 Receptor:88 nM (Ki) |
| In Vitro | S1R agonist 2 (Compound 8b; 0.1-5 μM) 均能显著增加神经生长因子 (NGF) 诱导的神经突生长，且呈剂量依赖性[1]。 S1R agonist 2 (24 h) 在 SHSY5Y 细胞中浓度为 1 μM 时对 Rotenone (HY-B1756) 诱导的细胞损伤有显著的抑制作用[1]。 S1R agonist 2 (0.1-5 μM; 24 h) 在 SHSY5Y 细胞中对 NMDA 刺激有神经保护作用[1]。 S1R agonist 2 (0-10 μM; 24-72 h) 对 A549、LoVo 和 Panc-1 细胞无细胞毒性[1]。 |
| In Vivo | S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) 在 10 μM 浓度下不诱导胚胎死亡 (100%存活胚胎)，但在最高剂量 (50 μM) 下诱导所有胚胎死亡[1]。 |
| References |
| Molecular Formula | C21H27NO |
|---|---|
| Molecular Weight | 309.45 |