804518-63-6
804518-63-6 structure
- Name: Yonkenafil
- Chemical Name: Yonkenafil
- CAS Number: 804518-63-6
- Molecular Formula: C24H33N5O4S
- Molecular Weight: 487.61
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2023-06-19 17:25:53
- Modify Date: 2024-01-13 21:51:45
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Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease[1].
| Name | Yonkenafil |
|---|
| Description | Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease[1]. |
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| Related Catalog | |
| In Vivo | Yonkenafil (4-32 mg/kg, i.v. daily for 7 days) 能够改善中风后的行为结果并减少脑梗塞体积，抑制神经元凋亡，并通过调节 BDNF/TrkB 和 NGF/TrkA 的表达显着增强缺血脑中的突触功能[1]。 Animal Model: Male Sprague-Dawley (SD) Rat[1] Dosage: 4, 8, 16 and 32 mg/kg Administration: i.v. daily for 7 days Result: Induced a dose-dependent decrease in infarct volume, with an ED50 of 12.27 mg/kg. Increased hsp70 expression, decreased apaf-1 expression, and inhibited caspase-3 and caspase-9 cleavage. Significantly prevented neuronal damage and increases the number of surviving neurons after stroke. Prevented decrease in synaptophysin levels and increase in PSD-95 and nNOS levels. |
| References |
| Molecular Formula | C24H33N5O4S |
|---|---|
| Molecular Weight | 487.61 |