Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-N-Boc-Piperazine
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: CAS:57260-71-6 tert-Butyl 1-piperazinecarboxylate
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Purity: 99.0%
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57260-71-6

57260-71-6 structure

57260-71-6 structure

Name: N-Boc-piperazine
Chemical Name: 1-Boc-piperazine
CAS Number: 57260-71-6
Molecular Formula: C₉H₁₈N₂O₂
Molecular Weight: 186.251
Catalog: Pharmaceutical intermediate Heterocyclic compound Piperazine
Create Date: 2018-07-12 23:22:13
Modify Date: 2026-06-30 08:33:25
N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].

Name	1-Boc-piperazine
Synonyms	N-(TERT-BUTYLOXYCBONYL)-PIPERAZINE tert-butyl piperazine-1-cboylate tert-butyl piperazine-1-cbox N-(tert-Butoxycbonyl)piperazine, tert-Butyl piperazine-1-cboxylate tert-Butyl 1-piperazinecboxyl 1-(tert-Butoxycbonyl)piperazine~tert-Butyl 1-piperazinecboxylate 1-Piperazinecboxylic Acid tert-Butyl Este tert-butyl piperazine-1-carboxylate tert-Butyl 2-piperazinecboxylate 1,1-Dimethylethyl 1-piperazinecarboxylate 1-BOC-Piperazine MFCD00075265 tert-butyl tetrahydropyrazine-1(2H)-carboxylate 1-(tert-Butyloxycbonyl)piperazine tert-Butyl 1-piperazinecboxylate，1-N-Boc-Piperazine N-BOC-PIPERAZINE RECHEM PA 0026 tert-Butyl 1-piperazincboxylate RARECHEM AR PA 0026 piperazine-1-carboxylic acid tert-butyl ester TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CBOXYLATE PIPERAZINE-1-CBOXYLIC ACID TERT-BUTYL ESTER 2-Methyl-2-propanyl 1-piperazinecarboxylate t-Butyl 1-piperazincboxylate N-(T-BUTYLOXYCBONYL)-PIPERAZINE Avatrombopag Impurity 28 N-Boc-piperazine hydrochloride 1-Boc-piperazine >= N-Boc-piperazine [N-(tert-Butoxycbonyl)-piperazine] Tertbutylpiperzine-1-cboxylate (N-Boc-piperazine) 1-Piperazinecboxylic Acid 1,1-Dimethylethyl Ester 1-Piperazinecboxylic Acid tert-Butyl Ester 1-N-BOC-PIPERAZINE BOC-PAZ tert-butyl piperazine-1-cboxylate(SALTDATA: FREE) BOC-PAZ/1-Boc-piperazine 1-(TERT-BUTOXYCBONYL)PIPERAZINE N-(TERT-BUTOXYCBONYL)PIPERAZINE TERT-BUTYL 1-PIPERAZINECBOXYLATE BOC-PIPERAZINE TERT-BUTYL N-PIPERAZINE N-(T-BOC)PIPERAZINE t-BUTYL PIPERZINE-1-CBOXYLATE 1-Boc piperzine t-Butyl 1-piperazincarboxylate 1,1-Dimethylethyl 1-piperazinecboxylate Piperazine, N1-BOC protected 1-(tert-Butoxycbonyl)piperazine > 1-BOC-PIPERAZINE, PIPERAZINE-1-CBOXYLIC ACID TERT-BUTYL ESTER tert-butyl l-piperazinecarboxylate 1-Boc-piperazine,tert-Butyl piperazine-1-cboxylate tert-Butyl 1-piperazinecboxylate ISO 9001：2015 REACH tert-Butyl 1-piperazinecboxylate, R N-Boc-piperazine; tert-butyl piperazine-1-carboxylate Tert-Butyl 1-Piperazinecboxylate1 tert-Butyl 1-piperazinecarboxylate 1-BOC-PIPERAZINE hydrochloride N - bok - piperazine 1-Piperazinecarboxylic acid, 1,1-dimethylethyl ester 1-[(1,1-DiMethylethoxy)carbonyl]piperazine PIBOC N Boc-Piperazine BUTTPK 52 N-T-BUTOXYCBONYLPIPERAZINE

Description	N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.

Density	1.0±0.1 g/cm3
Boiling Point	258.0±15.0 °C at 760 mmHg
Melting Point	47-49ºC
Molecular Formula	C₉H₁₈N₂O₂
Molecular Weight	186.251
Flash Point	109.8±20.4 °C
Exact Mass	186.136826
PSA	41.57000
LogP	0.55
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.467
Storage condition	Refrigerator

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Precursor 9
110-85-0 24424-99-5 164331-38-8 219509-79-2
57260-70-5 121370-60-3 1076-22-8 3355-28-0
85-18-7
DownStream 10
1072027-36-1 327030-39-7 38212-33-8 497915-42-1
40172-95-0 374930-88-8 39512-50-0 492431-11-5
509073-62-5 494773-35-2

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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