Shanghai Nianxing Industrial Co., Ltd
China
Product Name: N-Boc-piperazine
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: N-Boc-piperazine
Price: ￥90.0/25g ￥248.0/100g ￥918.0/500g
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: N-Boc-piperazine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-N-Boc-Piperazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: CAS:57260-71-6 tert-Butyl 1-piperazinecarboxylate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

57260-71-6

57260-71-6 structure

57260-71-6 structure

Name: N-Boc-piperazine
Chemical Name: 1-Boc-piperazine
CAS Number: 57260-71-6
Molecular Formula: C₉H₁₈N₂O₂
Molecular Weight: 186.251
Catalog: Pharmaceutical intermediate Heterocyclic compound Piperazine
Create Date: 2018-07-12 23:22:13
Modify Date: 2024-01-02 15:57:17
N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].

Name	1-Boc-piperazine
Synonyms	piperazine-1-carboxylic acid tert-butyl ester 1-Piperazinecarboxylic acid, 1,1-dimethylethyl ester BOC-PIPERAZINE 2-Methyl-2-propanyl 1-piperazinecarboxylate 1-Boc piperzine t-Butyl 1-piperazincarboxylate tert-butyl piperazine-1-carboxylate 1,1-Dimethylethyl 1-piperazinecarboxylate 1-BOC-Piperazine PIBOC MFCD00075265 tert-butyl tetrahydropyrazine-1(2H)-carboxylate N-BOC-PIPERAZINE tert-butyl l-piperazinecarboxylate 1-N-BOC-PIPERAZINE RARECHEM AR PA 0026 BOC-PAZ N-Boc-piperazine; tert-butyl piperazine-1-carboxylate tert-Butyl 1-piperazinecarboxylate N-Boc-piperazine N Boc-Piperazine

Description	N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.

Density	1.0±0.1 g/cm3
Boiling Point	258.0±15.0 °C at 760 mmHg
Melting Point	47-49ºC
Molecular Formula	C₉H₁₈N₂O₂
Molecular Weight	186.251
Flash Point	109.8±20.4 °C
Exact Mass	186.136826
PSA	41.57000
LogP	0.55
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.467
Storage condition	Refrigerator

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Precursor 9
110-85-0 24424-99-5 164331-38-8 219509-79-2
57260-70-5 121370-60-3 1076-22-8 3355-28-0
85-18-7
DownStream 10
1072027-36-1 327030-39-7 38212-33-8 497915-42-1
40172-95-0 374930-88-8 39512-50-0 492431-11-5
509073-62-5 494773-35-2

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%