2097497-16-8

2097497-16-8 structure

Name: Anticancer agent 109
Chemical Name: Anticancer agent 109
CAS Number: 2097497-16-8
Molecular Formula: C₁₉H₁₅N₃O₂
Molecular Weight: 317.34
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK TAM Receptor
Create Date: 2023-09-17 17:27:51
Modify Date: 2024-02-22 10:30:50
Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].

Name	Anticancer agent 109

Description	Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor
Target	Axl
References	[1]. Bae D, et al. Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis. Eur J Med Chem. 2023 May 5;251:115274.

Molecular Formula	C₁₉H₁₅N₃O₂
Molecular Weight	317.34