Anticancer agent 109

Modify Date: 2024-02-22 10:30:50

Anticancer agent 109 Structure
Anticancer agent 109 structure
Common Name Anticancer agent 109
CAS Number 2097497-16-8 Molecular Weight 317.34
Density N/A Boiling Point N/A
Molecular Formula C19H15N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anticancer agent 109


Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].

 Names

Name Anticancer agent 109

 Anticancer agent 109 Biological Activity

Description Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].
Related Catalog
Target

Axl

References

[1]. Bae D, et al. Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis. Eur J Med Chem. 2023 May 5;251:115274.  

 Chemical & Physical Properties

Molecular Formula C19H15N3O2
Molecular Weight 317.34
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