2245272-16-4

2245272-16-4 structure

Name: Antitumor agent-104
Chemical Name: Antitumor agent-104
CAS Number: 2245272-16-4
Molecular Formula: C₃₁H₃₃FN₆O₃
Molecular Weight: 556.63
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2023-09-29 20:12:47
Modify Date: 2024-04-06 12:06:22
Antitumor agent-104 (Compound 9) is an antitumor agent by inhibiting DNA damage repair in tumors. Antitumor agent-104 inhibits PARP1 enzymatic activity and the PAR protein level. Antitumor agent-104 also inhibits the expression of CDK12[1].

Name	Antitumor agent-104

Description	Antitumor agent-104 (Compound 9) is an antitumor agent by inhibiting DNA damage repair in tumors. Antitumor agent-104 inhibits PARP1 enzymatic activity and the PAR protein level. Antitumor agent-104 also inhibits the expression of CDK12[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Lin S, et al. Synthesis of Novel Dual Target Inhibitors of CDK12 and PARP1 and Their Antitumor Activities in HER2-Positive Breast Cancers. ACS Omega. 2023 Jul 7;8(28):25574-25581.

Molecular Formula	C₃₁H₃₃FN₆O₃
Molecular Weight	556.63