2691174-27-1

2691174-27-1 structure

Name: BBDDL2059
Chemical Name: BBDDL2059
CAS Number: 2691174-27-1
Molecular Formula: C₂₇H₃₆N₄O₄S
Molecular Weight: 512.66
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2023-10-12 16:20:25
Modify Date: 2024-01-14 09:10:03
BBDDL2059 is a selective covalent inhibitor of histone methyltransferase EZH2 with an IC50 of 1.5 nM for EZH2-Y641F. BBDDL2059 inhibits lymphoma cell growth at nanomolar concentrations and can be used for anticancer research[1].

Name	BBDDL2059

Description	BBDDL2059 is a selective covalent inhibitor of histone methyltransferase EZH2 with an IC50 of 1.5 nM for EZH2-Y641F. BBDDL2059 inhibits lymphoma cell growth at nanomolar concentrations and can be used for anticancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	EZH2 Y641F mutant type:1.5 nM (IC50)
References	[1]. Zhang Y, et.al. Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2. J Med Chem. 2023 Jun 8;66(11):7629-7644.

Molecular Formula	C₂₇H₃₆N₄O₄S
Molecular Weight	512.66